Prediction of the cardiac muscle force-velocity relation from its force-time and force-length relations

Article type: Research Article

Authors: Chadwick, R.S.

Affiliations: Theoretical Biomechanics Group/Mechanical Engineering Section, Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, Bethesda, MD20892, USA

Note: [] Accepted by: Editor J.-F. Stoltz

Abstract: The force-velocity relation for cardiac muscle fibers can be calculated from a proposed constitutive law based on force-time and force-length data. The calculated force-velocity relation agrees quite well with the measured force-velocity relation obtained from a quick release of sarcomere controlled rat cardiac trabeculae. The theory confirms the measured linear relationship between maximal velocity of sarcomere shortening and sarcomere length. The implication is that the force-velocity relation is not an independent property, and therefore need not be explicitly included as a rheological element in the constitutive law.

Keywords: Model, Theoretical Model, Myocardial Contraction, Cardiac Muscle Rheology

DOI: 10.3233/BIR-1991-283-408

Journal: Biorheology, vol. 28, no. 3-4, pp. 171-176, 1991