Flow characteristics of red cell containing fluids through pores. The effect of filter plugging, a mathematical model

Article type: Research Article

Authors: Crawford, Ralph G.^{; *} | Moss, Richard D.^{; **} | Gruemer, H.-D.

Affiliations: From the Section of Clinical Chemistry, Department of Pathology, Medical College of Virginia, Richmond, VA 23298

Note: [*] Present address: Chemistry Laboratory, St., Vincent’s Hospital, 153 W. 11th St., New York, NY 10011.

Note: [**] Present address: Lim Technology Laboratories, 409 E. Main St., Richmond, VA 23219.

Note: [] Accepted by: Editor R. Skalak

Abstract: A mathematical model was developed that describes the effects of filter plugging on flow through 3 μm pore polycarbonate filters as a function of time, pressure, and cell concentration, both under stirring and nonstirring conditions. The mathematical constants for the model were derived from experimental data generated with a filtration apparatus, and were tested by using various concentrations of cells that are able to plug filter pores. A computer simulation program was written to test the model over a wide range of nonfilterable cell concentrations.

Keywords: Microsieving, plugging, Nuclepore filters, non-filterable cells

DOI: 10.3233/BIR-1987-24107

Journal: Biorheology, vol. 24, no. 1, pp. 63-76, 1987