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Article type: Research Article
Authors: Schneditz, D.a | Rainer, F.b | Kenner, T.a
Affiliations: [a] Institute of Physiology, Harrachgasse 21/V, University of Graz, 8010-Graz, Austria | [b] Department of Internal Medicine, Auenbruggerplatz 11, University of Graz, 8010-Graz, Austria
Note: [] Accepted by: Editor D. Liepsch
Abstract: Red blood cell (REC) aggregation is known to be of deciding influence on erythrocyte sedimentation-rate (ESR) and on whole blood viscoelastic properties. The rheological behaviour of blood collected from a control-group with normal ESR is compared to the viscoelastic behaviour of blood collected from two groups with high to very high ESR, whose individuals are suffering from chronical polyarthritis and Morbus Bechterew, respectively. The rheological properties are evaluated by means of an oscillating-flow capillary-rheometer where the viscous (η′) and elastic (η″) component of the complex viscosity (η∗) is measured at a constant frequency of 2 Hz. Correcting for the varying hematocrit of the different blood samples according to an exponential equation, the viscoelastic data are found to be elevated in the groups with high ESR. For the viscous properties this is only due to the increase of the plasma viscosity. A correction for the plasma viscosity, however, shows that the viscous properties at low shear-rates (2s−1) are significantly reduced, whereas elastic properties in a range of medium shear-rates (10s−1 to 50s−1) are significantly increased (P < 0.001, t-test of Student). This result is discussed to be due to the high packing density of the RBC in fast sedimenting aggregates. High packing density reduces the effective volume of the REC but increases the stiffness of the aggregates.
Keywords: erythrocyte-aggregation, erythrocyte sedimentation-rate, viscoelasticity
DOI: 10.3233/BIR-1987-24103
Journal: Biorheology, vol. 24, no. 1, pp. 13-22, 1987
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