Selected methods for the evaluation of the effects of drugs on mucus viscoelasticity and mucociliary clearance

Issue title: New Methods in Biorheology. Proceedings of the International Symposium held in Nancy, France, 17–18 August 1983. A Satellite Symposium of the Fifth International Congress of Biorheology

Guest editors: J.F. Stoltz and E. Puchelle

Article type: Research Article

Authors: Bell, Alan E. | James, Stuart L. | Marriott, Christopher

Affiliations: Department of Pharmacy, Brighton Polytechnic, Moulsecoomb, Brighton BN2 4GJ, England

Abstract: In order to rationally test the efficacy of mucolytic and mucospissic compounds, their effects upon mucus viscoelasticity, ciliary beat frequency (c.b.f.) and total mucociliary transport rate (t.t.r.) must all be determined. Methods are described which allow the measurement of the viscoelastic modulii of small (10μL) quantities of mucus, while c.b.f. and t.t.r. are determined using the frog palate model.

Keywords: mucus, mucociliary, mucolytic, viscoelasticity

DOI: 10.3233/BIR-1984-23S123

Journal: Biorheology, vol. 23, no. s1, pp. 127-130, 1984