Surface rheological properties of hyaluronic acid solutions

Article type: Research Article

Authors: Kerr, H.R. | Warburton, B.

Affiliations: The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, England

Note: [] Accepted by: Editor A. Maroudas

Abstract: Using an oscillating ring surface rheometer,surface shear rheological studies of hyaluronic acid solutions at physiological pH have demonstrated the elastico-viscous nature of the surface films. The properties of these surface films change with time and are shown to be related to bulk concentration, ionic strength and pH. This ageing behaviour can be explained on the basis of molecular conformational changes and molecular segmental kinetics. The results are discussed in relation to the postulated function of hyaluronic acid in synovial fluid.

Keywords: Rheology, Hyaluronic Acid, Surface

DOI: 10.3233/BIR-1985-22204

Journal: Biorheology, vol. 22, no. 2, pp. 133-144, 1985