Affiliations: [a] Laboratoire de Biophysique, U.E.R. Biomedicale des Sts-Péres, 45, Rue des Sts-Perés 75006 Paris | [b] Laboratoire de Biophysique, U.E.R. Médicale de Bobigny, 74, Rue Marcel Cachin 93000 Bobigny | [c] Bioengineering Institute, Department of Civil Engineering and Engineering Mechanics Columbia University, New York, NY 10027
Note: [] Accepted by: Editor D. Quemada
Abstract: Filtration experiments through 5 or 3μ Nuclepore membranes are often performed in order to assess the so-called erythrocyte deformability. The relation between this parameter and the RBC filterability is not straightforward. A simple theoretical treatment relating filtration index (as determined by the initial flow rate method) to the average RBC flow resistance through an average pore is presented. In order to deduce the average RBC transit time through the membrane from the initial flow rate data, the suspension hematocrit change after filtration has been determined. The calculated average transit time is comparable to experimental values, as determined by Kiesewetter et al. with the single pore technique.
Keywords: Rigidity index, Erythrocyte deformability, Erythrocyte filtrability, Membrane transit times
DOI: 10.3233/BIR-1983-20605
Journal: Biorheology, vol. 20, no. 6, pp. 779-787, 1983
