On fundamental and phenomenological models, structure and mechanical properties of collagen, elastin and glycosaminoglycan complexes

Article type: Research Article

Authors: Viidik, A. | Danielsen, C.C. | Oxlund, H.

Affiliations: Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, University Park, DK-8000 Aarhus C, Denmark

Note: [] Accepted by: Guest Editors S. Woo and K. Hayashi

Abstract: This paper reviews the structure (fran molecular to macroscopic level) of collagen, elastin and glycosaminoglycans, with special reference to their functional properties and to how their behavior can be elucidated from in vitro manipulations of the tissues by biochemical means. Modes to analyse the mechanical behavior are briefly discussed and examplified by data from reconstituted collagenous “tissue”. It is concluded that the basic equation for the “non-linear elasticity” component in Fung’s law (and for the reconstituted “tissue” a modification of it) is a powerful tool for analysis of the physiological range of the stress-strain curve. Further, enzymatic “dissection” of one tissue element at a time provides a valuable method for the analysis of tissue element interactions. This approach is illustrated with data fran aortic tissue. It is shown that the mechanical properties of the aorta depend on an interaction between elastic and collagenous elements and that the strength of the tissue is not derived from its collagen fibers per se.

Keywords: collagen, elastin, glycosaminoglycans, biomechanics, morphology, biochemical structure

DOI: 10.3233/BIR-1982-19305

Journal: Biorheology, vol. 19, no. 3, pp. 437-451, 1982