Hemorheological and biochemical parameters in the “fatty” rat

Issue title: Proceedings of the Fourth International Congress of Biorheology. Jikei University School of Medicine, Tokyo, Japan, 27 July – 1 August 1981. Dedicated to Alex Silberberg

Guest editors: Alfred L. Copley

Article type: Research Article

Authors: Gaillard, S.^a | Delhon, A.^b | Laurresergues, H.^b | Stoltz, J.F.^a

Affiliations: [a] Groupe d’hémorhéologie, C.R.T.S. Brabois, 54500 Vandoeuvre-Nancy, France | [b] Centre de Recherche de Recherche P. Fabre, 81106 Castres, France

Note: [] Accepted by: Editor D. Quemada

Abstract: The essential part played by rheological factors in genesis of thrombosis and atherosclerosis has often been mentioned. Thus the authors have carried out a study of rheological and biochemical parameters on a genetic animal model with modifications in plasma lipids (homozygous obese “Fatty” rat) compared to the non obese heterozygous animal. The results obtained for the evolution of biochemical parameters (blood glucose, cholesterol, triglycerids) over a 16 months period confirm those published earlier. Further, a significant increase in fibrinogen level was observed in homozygous animals, and correlated with plasma viscosity. These results are also connected with changes in apparent blood viscosity which is considerably increased in homozygous rats, particularly at low shear rates (γ˙ < 20 s−1). These results show the value of this animal model and the authors suggest the application of such a genetic animal model and of its heterozygous control population to both theoretical rheological and pharmacological studies on atherogenesis and hyperlipoproteinaemia.

Keywords: hemorheology, animal model, Fatty rat, fibrinogen

DOI: 10.3233/BIR-1982-191-237

Journal: Biorheology, vol. 19, no. 1-2, pp. 353-362, 1982