Influence of oxygen tensions, intracellular enzymes and hematological factors on RBC filterability

Issue title: Perspectives in Biorheology. Festschrift for A.L. Copley

Guest editors: Alexander Silberberg

Article type: Research Article

Authors: Rusch, Ph.^a | Herrmann, T.^a | Geyssant, A.^b | Vasselon, C.^c | Champailler, A.^a | Healy, J.C.^a

Affiliations: [a] Laboratoire de Biophysique, UER de Médecine, 30 rue F. Gambon 42100, Saint-Etienne France (for reprints) | [b] Laboratoire de Physiologie, UER de Médecine, 30 rue F. Gambon 42100, Saint-Etienne France | [c] Centre de Transfusion Sanguine, Hôpital Bellevue, Boulevard Pasteur, 42100 Saint-Etienne, France

Note: [] Invited by: Editor A. Silberberg

Abstract: Using a new automatic device and a standardised protocole for looking the filterability of erythrocytes through 5 μ pores, we introduced the IF (Index of Filterability) parameter. We demonstrate that IF is dependent on the viscoelastic properties of RBC membranes when Hb is normal, and dependent on Hb and O2 saturation of Hb when Hb is unstable (Thalassemia or drepanocytosis). The molecular interpretation and the interest of that for clinical screening or extensive studies are discussed.

Keywords: Red blood cells, Filterability, Oxygen tension, Hematocrit, Intracellular Enzymes

DOI: 10.3233/BIR-1981-183-614

Journal: Biorheology, vol. 18, no. 3-6, pp. 493-499, 1981