Shear inactivation of heparin

Article type: Research Article

Authors: Charm, Stanley E. | Wong, Bing L.

Affiliations: New England Enzyme Center and Department of Physiology, Tufts University, School of Medicine, Boston, MA02111

Abstract: 11The title of the paper and the abstract differ from that originally published in Biorheology 12, 81, 1975 and was not corrected earlier by the authors-ALC and MJ. Shear inactivation of heparin is an important factor in its loss of anticoagulant activity. It is possible to predict the anticoagulant activity loss of heparin in plasma or water circulated through a teflon capillary tube. The shear inactivation of heparin in coating on implanted prosthetics may be calculated and is in close agreement with the literature data. Comparison of loss in heparin activity by shear inactivation calculated for the circulation is in close agreement with the unaccounted loss reported in the literature.

DOI: 10.3233/BIR-1975-12504

Journal: Biorheology, vol. 12, no. 5, pp. 275-278, 1975