Prediction of concentration profiles during erythrocyte sedimentation by a hindered settling model

Article type: Research Article

Authors: Sartory, W.K.

Affiliations: Reactor Division and Molecular Anatomy Program, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Note: [*] NIH-AEC Molecular Anatomy Program is jointly sponsored by the National Cancer Institute, the National Institute of General Medical Sciences, the National Institute of Allergy and Infectious Diseases, and the U.S. Atomic Energy Commission. The Oak Ridge National Laboratory is operated by Union Carbide Corporation for the U.S. Atomic Energy Commission.

Abstract: The effect of diffusion on the sedimentation of erythrocytes is reexamined analytically. and it is concluded that the diffusivity of erythrocytes is too small by several orders of magnitude to account for the available experimental results. An alternative monodisperse hindered sedimentation model is found to give fairly good agreement with the available experiments, at least after 1 hr. A polydisperse hindered sedimentation model is considered briefly, but it is found to be unable to completely account for the limitations of the monodisperse model.

DOI: 10.3233/BIR-1974-11405

Journal: Biorheology, vol. 11, no. 4, pp. 253-264, 1974