Affiliations: Department of Biomedical Engineering and Center for Computational Medicine and Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA | Department of Bioengineering, M0412, University of California, San Diego, La Jolla, CA 92093‐0412, USA
Note: [] Corresponding author: Dr Bigyani Das, Ph.D., Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA. Tel.: +1 410 955 1787; Fax: +1 410 614 8796; E‐mail: [email protected].
Abstract: The study of the effect of leukocyte adhesion on blood flow in small vessels is of primary interest to understand the resistance changes in venular microcirculation. Available computational fluid dynamic studies provide information on the effect of leukocyte adhesion when blood is considered as a homogeneous Newtonian fluid. In the present work we aim to understand the effect of leukocyte adhesion on the non‐Newtonian Casson fluid flow of blood in small venules; the Casson model represents the effect of red blood cell aggregation. In our model the blood vessel is considered as a circular cylinder and the leukocyte is considered as a truncated spherical protrusion in the inner side of the blood vessel. The cases of single leukocyte adhesion and leukocyte pairs in positions aligned along the same side, and opposite sides of the vessel wall are considered. The Casson fluid parameters are chosen for cat blood and human blood and comparisons are made for the effects of leukocyte adhesion in both species. Numerical simulations demonstrated that for a Casson fluid with hematocrit of 0.4 and flow rate Q=0.072 nl/s, a single leukocyte increases flow resistance by 5% in a 32 μm diameter and 100 μm long vessel. For a smaller vessel of 18 μm, the flow resistance increases by 15%.
