Inhibition of cathepsin activities by vitamin B_{6} derivatives

Article type: Abstract

Authors: Matsui, A. | Tsuzuki, H. | Murata, E. | Tada, Y. | Asao, T. | Katunuma, N.

Affiliations: Tokushima Bunri University, Institute for Health Sciences, Tokushima 770, Japan | Central Institute of Taiho Pharmaceutical Co. Hanno, Japan

Abstract: We found that pridoxal phosphate (PLP), a coenzyme form of vitamin B_{6}, inhibited the activity of cathepsins B, K, S and L in vitro. Cathepsins activities in cultured splenocytes were suppressed by the addition of pridoxal (PL) or pridoxine (PI) in to the culture medium. A newly synthesized artificial vitamin B_6 derivative, a pridoxal propionate derivative, CLIK‐164, showed selective inhibition of cathepsin O/K.

Keywords: Cathepsin B, cathepsin L, cathepsin K, pridoxal, pridoxal phosphate

Journal: Biofactors, vol. 11, no. 1-2, pp. 117-120, 2000