Note: [] Address for correspondence: Dr Khaled Hamden, Laboratory of
Animal Ecophysiology, Faculty of Sciences, PB 802, 3018, Sfax; University of
Sfax, Tunisia. Tel.: +216 97 469 111; Fax: +216 74 274 437; E-mail:
[email protected]/ [email protected]
Abstract: In the current study, the effect of Ajuga iva extract on blood
glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme
activities in alloxan-induced diabetic rats was investigated. Diabetes was
confirmed by measuring the glucoserua concentration 15 days after alloxan
administration. Ajuga iva extract was administrated orally 3 weeks after
alloxan injection. Our results investigate that Ajuga iva extract
supplementation increased the levels of both enzymatic antioxidant (superoxide
dismutase, catalase and gluthation peroxidase) and metals antioxidants (iron,
copper, magnesium, calcuim) and decreased lipid peroxidation level (TBARs).
Besides Ajuga iva ameliorated diabetes provoked hepatic and renal
toxicity appeared by a lower level in total and direct bilirubin, urea,
creatinine, triglyceride (TG), cholesterol and a higher level in
HDL-cholesterol. Besides, the activities of phosphatase alkalines (PAL),
aspartate and lactate transaminase (AST & ALT) were decreased. The
benefices effects of phytoecdysteroids of Ajuga iva confirmed by
histological observation in pancreatic tissues. In conclusion, Ajuga iva phytoecdysteroids supplements seem
to be beneficial for correcting the hyperglycemia and preventing diabetic
complications in liver, pancreas and kidneys.
Keywords: Ajuva iva, diabetes, toxicity, liver and kidney, histological changes, therapeutic and preventive effects
Journal: BioFactors, vol. 33, no. 3, pp. 165-175, 2008
