Affiliations: Shiseido Life Science Research Center, Kanagawa,
Japan
Note: [] Address for correspondence: Tomonobu Ezure, M.S., Shiseido Life
Science Research Center, 2-2-1, Hayabuchi, Tsuzuki-ku, Yokohama-shi, Kanagawa
224-8558, Japan. Tel.: +81 45 590 6047; Fax: +81 45 590 6087; E-mail:
[email protected]
Abstract: Adipocytes were recently shown to secrete adipocytokines, such as
adiponectin and leptin, which may have an endocrine role. Subcutaneous adipose
tissue lies just beneath the dermis, and dermal condition is correlated with
body mass index (BMI). However, it is not clear whether adipocytokines released
by adipocytes in subcutaneous adipose tissue influence the adjacent dermis. We
found that human dermal fibroblasts express genes encoding receptors for
adiponectin and leptin, and that those cytokines both significantly increase
production of hyaluronic acid (HA), a major extracellular matrix component
(ECM) of dermis, by dermal fibroblasts. This effect is accompanied with
up-regulation of HA synthase 2 gene expression. Moreover, adiponectin
significantly increases production of collagen, the most abundant component of
ECM in dermis, by dermal fibroblasts. These results suggest that subcutaneous
adipocytes influence dermal condition by up-regulating collagen and HA
production by dermal fibroblasts via secretion of adiponectin and leptin.
