Affiliations: Hong Kong Applied Science and Technology Research
Institute Company Limited, Hong Kong, HKSAR, China | Department of Radiology, Mayo Clinic and Foundation,
Rochester, MN, USA
Note: [] Address for correspondence: Dr. Geng Li, Hong Kong Applied
Science and Technology Research Institute Company Limited, 5th Floor, Photonics
Centre, 2 Science Park East Avenue, Hong Kong Science Park, Shatin, New
Territories, Hong Kong, HKSAR, China. Tel.: +852 3406 2620; Fax: +852 3406
2802; E-mail: [email protected]
Abstract: We tested the hypotheses that supplemental intake of the diet
supplement Coenzyme Q_{10} (CoQ_{10})
could delay brain atrophy in double transgenic amyloid precursor protein (APP)
/ presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice
by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28
APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group
(n = 14 per group) was treated with
CoQ_{10} 2400 mg/kg/day, and the other half with placebo for
60 days. Magnetic resonance (MR) images were used to obtain the volumes of the
hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with
CoQ_{10} exhibited significantly less atrophy in hemisphere
and hippocampus than those receiving placebo. The neuro-protective effect of
the CoQ_{10} on hemispheric volume, and hippocampal volume
was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in
wild type mice. Our result indicated that CoQ_{10} may have
therapeutic potential in the prevention and treatment of MCI and AD.
