Affiliations: Laboratory of Nutritional Investigation and
Degenerative-Chronic Diseases, Federal University of Rio de Janeiro State
(UNIRIO), Rio de Janeiro (City), Brazil
Note: [] Address for correspondence: L.M. Vianna, Universidade Federal do
Estado do Rio de Janeiro – Laboratório de Investigação em
Nutrição e Doenças Crônico-Degenerativas-UNIRIO, Rua Xavier
Sigaud, 290 – Térreo, Urca. Zip code 22290-240, Rio de Janeiro City, Rio
de Janeiro State, Brazil. E-mail: [email protected]
Abstract: Decylubiquinone treatment in vitro has demonstrated a potent
inhibitor effect on reactive oxidative species production. However, the effect
in vivo has not been demonstrated yet. Thus, rats SHRSP male were divided
in two groups: treated and controls (n=6, each). The treated
group received 10 mg/Kg^{-}/body weight of decylubiquinone
diluted in coconut oil by oral gavage during four weeks. Control rats just
received the vehicle. Body weight, diuresis, food and water intake, systolic
blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol,
triglycerides, blood glucose levels and malondialdehyde were determined. There
were a significant (p<0.05) reduction on systolic blood
pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the
treated group. Additionally, HDL-cholesterol also increased significantly.
However, body weight, diuresis, food and water intake, blood glucose levels and
triglycerides did not alter after treatment. Thus, decylubiquinone can be a new
antihypertensive, hypolipidemic and antioxidant agent on the prevention and
treatment of diseases linked to oxidative stress.
