Affiliations: Department of Neurosurgery, The General Hospital of
Shenyang Military Region, Shenyang, P.R. China | State Key Laboratory of Genetic Engineering, Institute
of Genetics, School of Life Science, Fudan University, Shanghai, P.R.
China | Shanghai Neurosurgical Institute, The Department of
Neurosurgery of Changzheng Hospital, The Second Military Medical University,
Shanghai, P.R. China
Note: [] Address for correspondence: Yingqun Tao, Department of
Neurosurgery, The General Hospital of Shenyang Military Region, P.L.A. Wenhua
Road 83, Shenyang 110016, P.R. China. Tel.: +86 1335 2459949; Fax: +86 0416
2680427, E-mail: [email protected]
Abstract: Meningiomas, which originate from arachnoid cells and constitute the
largest subgroup of all intracranial tumors, are generally benign, yet have the
capacity to progress into a higher histological grade of malignancy associated
with an increase in biological aggressivity and/or capacity to recur. To
elucidate meningioma pathogenesis and malignancy, we applied a holistic and
network approach analyzing cDNA and tissue microarray results. A potential
pathway leading to meningioma angiogenesis, apoptosis and proliferation was
evidenced as well as a regulatory network of the biomarkers including Ki-67,
AR, CD34, P53, c-MYC, etc. which might support clinical research. In this
potential pathway, ITGB1 could be the most important "superoncogene" playing
a vital role in apoptosis and proliferation, while FOXO3A, MDM4 and MT3 are
important to the malignancy process. Some genes are first reported that could
explain why radiation induces meningioma and why more female than male patients
are affected. Further, we present the hypothesis that HIV-Tat protein might
have a close relationship with meningioma pathogenesis and malignancy.
Journal: BioFactors, vol. 28, no. 3-4, pp. 203-219, 2006
