Affiliations: Department of Biological Responses, Institute for
Virus Research, Kyoto University, 53 Shogoin Kawahara-cho Sakyo-ku, Kyoto
606-8507, Japan | Department of Experimental Therapeutics, Translational
Research Center, Kyoto University Hospital, 54 Shogoin, Kawahara-cho, Sakyo-ku,
Kyoto 606-8507, Japan
Note: [] Address for correspondence: Junji Yodoi, Department of
Biological Responses, Institute for Virus Research, Kyoto University, 53
Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Tel.: +81 75 751 4024;
Fax: +81 75 761 5766; E-mail: [email protected]
Abstract: Thioredoxin (TRX) binding protein-2 (TBP-2), a negative regulator of
TRX, is involved in intracellular redox regulation and cellular growth. The
expression of TBP-2 is frequently lost in tumor cell lines and tissues, whereas
the ectopic expression of TBP-2 suppresses cellular proliferation along with
cell cycle arrest at the G1 phase. TBP-2 was also reported to be a cellular
senescence-associated gene. Besides the retardation of cellular growth, the
reduction of white adipose, and alteration of the energy pathway are involved
in several features of the aging process. We have generated TBP-2 genetically
modified mice and found that TBP-2 is closely linked to lipid metabolism.
Indeed, TBP-2 has been suggesting to be related to familial combined
hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid
metabolism is one of the most primitive sources of energy production, we
discussed the possible roles of TBP-2 in the regulation of energy utilization
connected to the aging process.
Keywords: Thioredoxin, redox, aging, lipid, energy metabolism
Journal: BioFactors, vol. 27, no. 1-4, pp. 47-51, 2006
