Abstract: Green tea (Camellia sinensis), and CoQ_9 when
given to Wistar rats produced a partial reversal on reserpine induced oxidative
stress and liver damage. Green tea, with its abundant polyphenol
(-)Epigallocatechin 3-gallate (ECGC) and other catechins, is known for its
antioxidative characteristics influencing lipid metabolism. Ubiquinone,
abundant in heart muscle, is also a potent antioxidant with known effects in
numerous pathologies. However the combined effect of ECGC and ubiquninone has
not been reported. In the present study we found that green tea extract, when
given in combination with CoQ_9 to Wistar rats subjected to
oxidative stress, showed a statistically significant antioxidative effect.
Liver cholesterol level in rats receiving combination treatment was also
significantly lower than control or rats receiving green tea extract alone.
Reserpine induced liver damage in Wister rats was also partially reversed by a
treatment of green tea extract when combined with CoQ_9.
These results may have important clinical implications and may be extrapolated
for the treatment of patients suffering from liver damage due to hepatitis B/C
or liver cirrhosis.
Keywords: Green tea, Camellia sinensis, oolong, ubiquinone, CoQ[TeX:] _9, antioxidative
Journal: BioFactors, vol. 25, no. 1-4, pp. 255-259, 2005
