Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Haba, Ryota | Watanabe, Shaw | Wada, Masahiro | Udaka, Shigezo

Affiliations: Faculty of Applied Bioscience, Tokyo University of Agriculture 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan

Note: [] Address for correspondence: Shaw Watanabe, MD, DMS, 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan. Tel.: +81 3 5477 2670; Fax: +81 5477 7222; E-mail: [email protected]

Abstract: The cancer-preventive effects of food-derived bovine lactoferrin(bLF), isoflavone-rich soya germ(SG), and spermidine(SPD) on mammary gland carcinogenesis induced by 2-amino-1- methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), were investigated in female Sprague-Dawley(SD) rats. Two hundred and six female SD rats were divided into 8 groups. Cumulative breast cancer incidence at 43 weeks was 65.4% in the PhIP group; 80.0% and 76.0% in the 0.2% and 2.0% bLF groups, respectively; 58.3% and 20.0% in the 2% and 10% SG groups, respectively; and 80.0% and 76.9% in the 0.035% and 0.175% SPD groups, respectively. Isoflavone-rich SG significantly suppressed breast cancer, and the tumors showed fibrous or less malignant features upon histological examination.

Keywords: lactoferrin, isoflavone, polyamine, cancer prevention, mammary carcinogenesis

Journal: BioFactors, vol. 22, no. 1-4, pp. 127-131, 2004