Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-A^{y} mice

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Ohnishi, M. | Matuo, T. | Tsuno, T. | Hosoda, A. | Nomura, E. | Taniguchi, H. | Sasaki, H. | Morishita, H.

Affiliations: Kansai Shinkyu Medical University, 1-11, 2 Wakaba Kumatori Sennan, Osaka 590-0482, Japan | Tsuno Food industrial Co., LTD, 94 Shinden, Katsuragicho, Itogun, Wakayama 649-7194, Japan | Industrial Technology Center of Wakayama Prefecture, 60 Ogura Wakayama 649-6261, Japan | Wakayama University of Medical Science, 811-1 Kimiidera, Wakayama 641-8509, Japan | Faculty of Education, Wakayama University, 930 Sakaedani, Wakayama 640-8510, Japan

Note: [] Address for correspondence: Motoyo Ohnishi, Kansai Shinkyu Medical University, 1-11, 2 Wakaba Kumatori Sennan, Osaka 590-0482, Japan. Tel.: +81 724 53 8726, Fax: +81 724 53 8767; E-mail: [email protected]

Abstract: Antioxidant activity and biological properties of ferulic acid (FA) are well recognized. This study was designed to estimate the potential utility of FA administered orally at low dosage for improvement of hyperglycemia in diabetes. With this aim we have evaluated the hypoglycemic effect of FA in two type diabetic animal models: (1) streptozotocin (STZ)-induced diabetic mice, a model of insulin-dependent diabetes mellitus (IDDM); (2) KK-A^{y} mice, a model of non-insulin dependent diabetes mellitus (NIDDM). In addition, we measured the production of thiobarbituric acid-reactive substances (TBARS) in brown adipose tissues of diabetic mice at the end of FA feeding experiment. FA at 0.01% and 0.1% of basal diet showed to suppress significantly blood glucose levels in STZ-induced diabetic mice. In KK-A^{y} mice 0.05% FA suppressed effectively blood glucose levels. In addition, FA inhibited the lipid peroxidation in brown adipose tissue of diabetic mice. Taken together, these findings suggest that dietary FA may be useful in alleviating oxidative stress and attenuating the hyperglycemic response associated with diabetes.

Keywords: ferulic acid, hypoglycemic effect, diabetes, antioxidant activity, KK-A[TeX:] ^{y} mice, STZ-induced diabetic mice

Journal: BioFactors, vol. 21, no. 1-4, pp. 315-319, 2004