Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Iwai, Kunihisa | Kim, Mi-Yeon | Onodera, Akio | Matsue, Hajime

Affiliations: Division of Environmental Technology, Aomori Industrial Research Center, 4-11-6 Daini-tonyamachi, Aomori 030-0113, Japan | Onodera Brewhouse Co., 39 Zaifukojimachi, Sannohe Town, Aomori 039-0132, Japan | Aomori University of Health and Welfare, 58-1 Mase, Aomori 030-8505, Japan

Note: [] Corresponding author: Tel.: +81 17 739 9676; Fax: +81 17 739 9613; E-mail: [email protected]

Abstract: The fruit of Viburnum dilatatum Thunb, called gamazumi in Japan, showed the strong antioxidant activities, and its preventive effects on oxidative stress and active ingredients were investigated. Male rats were subjected to water immersion restraint stress for 6 hours, after ingestion of the gamazumi crude extract (GCE) for 2 weeks. The formation of gastric ulcer was reduced, and the lipid peroxidation in plasma and organs also lowered in rats ingested GCE. In the streptozotocin-induced diabetic rats given GCE for 10 weeks, inhibition of lipid peroxidation in plasma, erythrocytes and organs was observed, and the increase of plasma glucose level also lowered. On the other hand, two cyanidin glycosides, two chlorogenic acids and quercetin were identified, and especially cyanidin 3-sambubioside (Cy 3-sam) showed the strong radical scavenging activity. It is suggested that Cy 3-sam is a key compound contributing to the physiological effects of V. dilatatum fruit.

Keywords: Viburnum dilatatum, cyanidin 3-sambubioside, antioxidant, radical scavenging, diabetes

Journal: BioFactors, vol. 21, no. 1-4, pp. 273-275, 2004