Accumulation of copper in kidney of spontaneously hypertensive rats, a preliminary study

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Minakata, Kayoko | Kawai, Kaori | Horio, Fumihiko | Takeuchi, Hiroichi | Suzuki, Osamu

Affiliations: Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan | Department of Applied Molecular Biosciences, Nagoya University, Nagoya 464-0814, Japan | Department of Public Health, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan

Note: [] Corresponding author. Tel./Fax: +81 53 435 2233; E-mail: [email protected]

Abstract: Mineral levels such as Cu, Fe, Zn, Ca and Mg in organs of spontaneously hypertensive osteogenic disorder Shionogi rat (SHR-od) were compared with those of normotensive osteogenic disorder Shionogi rat (ODS). The effect of vitamin C deficiency was also examined for both strains. Cu levels in kidney of SHR-od increased to 2.2 times and 5.0 times that of ODS at 6-week old and 30-week old, respectively, although the effect of vitamin C deficiency was not observed in Cu levels of five organs examined. The effect of vitamin C deficiency appeared in the change in the other mineral levels almost similarly for both SHR-od and ODS rats at 30-week old; the decrease of Fe in liver, spleen and lung, whereas the increase of Zn in liver, Ca in heart and Mg in spleen, respectively.

Keywords: hypertension, osteogenic disorder Shionogi rat, copper, kidney, ascorbic acid

Journal: BioFactors, vol. 22, no. 1-4, pp. 29-31, 2004