Affiliations: Korea Food Research Institute, Kyongki-do, 463-746,
South Korea | Institute of Medical Science, School of Medicine,
Wonkwang University, Iksan 570-749, South Korea
Note: [] Address for correspondence: Myung-Sunny Kim, Ph.D., Korea Food
Research Institute, San 46-1, Baekhyon-dong, Pundang-ku, Songnam, Kyongki-do,
463-746, Republic of Korea. Tel.: +82 31 780 9229; Fax: +82 31 709 9876;
E-mail: [email protected]
Abstract: Garcinia extract was used as a potential anti-obesity agent. In this
study, we found that Garcinia extract inhibits the cytoplasmic lipid
accumulation as well as adipogenic differentiation of preadipocytes. The
mechanisms that regulate the inhibition of insulin-induced differentiation by
Garcinia extracts include the inhibition of expression of the early adipogenic
transcription factor, CCAAT element binding protein
(C/EBP)α that regulate adipogenesis. These results
suggest that the specific targets of Garcinia extract on differentiation
process of 3T3-L1 cells could be, at least, early adipogenic differentiation
factor.
Keywords: garcinia, C/EBPα, adipogenesis
Journal: BioFactors, vol. 22, no. 1-4, pp. 193-196, 2004
