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Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)
Article type: Research Article
Authors: Fukao, Tomomi | Hosono, Takashi | Misawa, Satomi | Seki, Taiichiro | Ariga, Toyohiko
Affiliations: Department of Nutrition and Physiology, Nihon University Graduate School of Applied Life Sciences, Nihon University College of Bioresource Sciences, Kanagawa, Japan
Note: [] Address for correspondence: Dr. Taiichiro Seki, Department of Nutrition and Physiology, Nihon University College of Bioresource Sciences, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. Tel./Fax: +81 466 84 3949; E-mail: [email protected]
Abstract: Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are principal constituents of garlic oil. We studied the effect of these sulfides on the phase II drug-metabolizing enzymes, and on the rat model of acute liver injury induced by carbon tetrachloride (CCl_{4}). A highly purified form of each sulfide (more than 99% purity) was administered i.p. to rats at a concentration of 10 or 100 μmol/kg body weight for 14 consecutive days. DATS (10 μmol/kg) and DADS at a 10-fold higher dose (100 μmol/kg) significantly increased the activities of glutathione S-transferase (GST) and quinone reductase (QR); whereas DAS did not. In the CCl_{4}-induced acute liver injury model of rats, DATS (10 μmol/kg) significantly suppressed the increase in plasma lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities. In conclusion, hepatic phase II enzymes were induced strongly by the trisulfide and weakly by the disulfide, but not by DAS. DATS significantly reduced the liver injury caused by CCl_{4}. DATS may be one of the important factors in garlic oil that protects our body against the injury caused by radical molecules.
Keywords: garlic, allyl sulfides, phase II enzymes, carbon tetrachloride, liver injury, chemoprevention
Journal: BioFactors, vol. 21, no. 1-4, pp. 171-174, 2004
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