The influence of antineoplastic chemotherapy on the glutathione enzymes activity in the blood

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Kopañski, Z.^; | Grabowska, M. | Kosiniak-Kamysz, A. | Bertrandt, J. | Kołodziejski, L. | Opoka, W. | Schlegel-Zawadzka, M.

Affiliations: Military Clinical Hospital, 1-3 Wrocławska str., 30-901 Kraków, Poland | Academy of Physical Education, 78 Al. Jana Pawła II, 31-571 Kraków, Poland | Jagiellonian University, Medical College, 7 Kopernika str., 31-034 Kraków, Poland | H. Dietl Hospital, 1 Skarbowa, 31-121 Kraków, Poland | Military Institute of Hygiene and Epidemiology, 4 Kozielska str., 01-163 Warszawa, Poland | Clinic of Oncological Surgery of the Oncology Institute, 11 Garncarska, 31-115 Kraków, Poland

Note: [] Corresponding author. E-mail: [email protected]

Abstract: The analysis included 78 patients (42 men and 36 women) aged 48 to 67 years treated with cytostatics because of a neoplastic disease. In all the patients examined was evaluated the influence of the chemotherapy carried out on the glutathione peroxidase (GPx) and glutathione reductase (GR) activities. It was confirmed that the effect of the action on the glutathione enzymes (GE) activity of the antineoplastic chemotherapy changes depending on the duration of the treatment with cytostatics. In the end this activity settles at a high level, statistically significantly higher than that registered before the beginning of the antineoplastic treatment. The increase of the GE activity is mainly favoured by the chemotherapy following the schemes FAC (5-fluorouracyl + doxorubicin + endoxan) and PAC (cisplatin + cyclofosfamide + pharmorubicin).

Keywords: anticancer chemotherapy, glutathione peroxidase and glutathione reductase PGx activities

Journal: BioFactors, vol. 22, no. 1-4, pp. 79-82, 2004