Affiliations: Department of Food & Health Science, Faculty of
Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama
700-8558, Japan | Department of Hepato-Biliary-Pancreatic Surgery, Osaka
City University Graduate School of Medicine, Osaka 545-8585, Japan
Note: [] Address for correspondence: Yukiko Minamiyama, PhD, Department
of Food & Health Science, Okayama University Graduate School of Medicine
and Dentistry, Shikata-cho, Okayama 700-8558, Japan. Tel.: +81 86 235 7491,
Fax: +81 86 235 7492; E-mail: [email protected]
Abstract: Natural antioxidants have been shown to be rich sources of
microchemicals with the potential to prevent human cancers. We examined whether
dietary supplement of a fermented grain food mixture (AOB), which has been
shown to have a strong antioxidative effect, may protect against colon cancer
metastasis. At day 5 of AOB (6.5%) supplementation in a basal diet, the rat
colon cancer cells (RCN-H4) were injected beneath the capsule of the spleen and
one min later rats were splenectomized. All rats without AOB supplementation
had multiple liver metastases. However, the number and the size of liver tumors
were reduced by about 80% in AOB group. Combined use of cisplatin and AOB
enhanced an anti-metastatic effect. The inhibition of liver metastasis by AOB
was caused by the regulation of cell cycle. This product may be used as an
adjuvant in the therapy of malignant neoplasia.
Keywords: fermented grain food, antioxidant, liver metastasis, rat
Journal: BioFactors, vol. 22, no. 1-4, pp. 67-69, 2004
