Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells

Issue title: The Third Conference of the International CoQ10 Association

Article type: Research Article

Authors: Quiles, J.L.^; | Farquharson, A.J. | Ramírez-Tortosa, M.C.^; | Grant, I. | Milne, L. | Huertas, J.R.^; | Battino, M. | Mataix, J.^; | Wahle, K.W.J.

Affiliations: Institute of Nutrition and Food Technology, University of Granada, Spain | Rowett Research Institute, Bucksburn, Aberdeen, UK | Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy | Department of Physiology, University of Granada, Spain | Department of Biochemistry and Molecular Biology, University of Granada, Spain

Note: [] Address for correspondence: Dr. José L. Quiles, Institute of Nutrition and Food Technology, C/ Ramón y Cajal 4 (Edif. Fray Luis de Granada), 18071 Granada, Spain. E-mail: [email protected]

Abstract: The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q_{10} in cancer therapy.

Keywords: ubiquinone, prostate cancer, antioxidants, gene expression

Journal: BioFactors, vol. 18, no. 1-4, pp. 265-270, 2003