Bioactive peptides derived from food proteins preventing lifestyle-related diseases

Article type: Research Article

Authors: Masaaki Yoshikawa, | Hiroyuki Fujita, | Nobuyuki Matoba, | Yasuyuki Takenaka, | Taichi Yamamoto, | Rena Yamauchi, | Hirotaka Tsuruki, | Kyoya Takahata,

Affiliations: Research Institute for Food Science, Kyoto University, Gokanosho, Uji, Kyoto 611-0011, Japan | Central Research Institute, Nippon Synthetic Chemical Industry Company, Ltd., Ibaraki, Osaka 567-0052, Japan | Faculty of Agriculture, Okayama University, Okayama 700-0082, Japan

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Abstract: Many kinds of bioactive peptides which might prevent lifestyle-related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I-converting enzyme (ACE) having anti-hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8-fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2--7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.

Keywords: peptide, lifestyle-related diseases, angiotensin I-converting enzyme inhibitor, vasorelaxation, cholesterol, immunostimulation, ovalbumin, soybean, [TeX:] \beta-lactoglobulin

Journal: BioFactors, vol. 12, no. 1-4, pp. 143-146, 2000