Affinity of polyphenols for lipid bilayers

Article type: Research Article

Authors: Tsutomu Nakayama, | Toshihiko Hashimoto, | Katsuko Kajiya, | Shigenori Kumazawa,

Affiliations: School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan

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Abstract: Interaction of tea catechins with lipid bilayers has been investigated with liposome systems. Epicatechin gallate had the highest affinity for lipid bilayers, followed by epigallocatechin gallate, epicatechin, and epigallocatechin. Epicatechin gallate and epigallocatechin gallate in the surface of lipid bilayer perturbed the membrane structure.

Keywords: catechins, polyphenols, EGCg, liposome, lipid bilayer

Journal: BioFactors, vol. 13, no. 1-4, pp. 147-151, 2000