Affiliations: Instituto de Nutrición y Tecnología de Alimentos, Universidad de Granada, Granada, Spain | Departamento de Fisiología, Universidad de Granada, Granada, Spain | Departamento de Bioquímica y Biologia Molecular, Universidad de Granada, Granada, Spain | Departamento de Bioquímica, Universidad de Ancona, Italy | Hospital Maternoinfantil de Granada, Granada, Spain
Note: [] Correspondence to: Jesús R. Huertas, Departamento de Fisiología, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain. E‐mail: [email protected].
Abstract: The most probable factor connecting premature infant problems such as retinopathy, intraventricular hemorrhage and chronic lung disease appears to be the excessive production of oxygen free radicals which can occur as a consequence of oxygen therapy. The aim of our investigation was to elucidate the possible correlations between lipid peroxidation, in this study measured as hydroperoxides production, and antioxidant concentrations in erythrocyte membranes of both full term and preterm infants. Hydroperoxide concentrations were found to be high, especially in premature infants, in erythrocyte membranes at birth and in the initial days of life. The erythrocyte membranes were also found to contain low levels and/or low activites of antioxidant defense mechanisms which was more evident in premature newborns where \alpha‐tochopherol levels were significantly lower in comparison to full term infant levels. Furthermore, when premature infants undergo oxygen therapy these effects were exacerbated. These results demostrate that at birth, particulary in the premature newborn, the degree of oxidative stress outweighs the antioxidant defense mechanisms.
Journal: Biofactors, vol. 8, no. 1-2, pp. 133-137, 1998
