Affiliations: Intitute of Biochemistry, | Institute of Microbiology and Biomedical
Sciences, | Institute of Human Morphology, | Istituto di Anatomia Patologica, | Institute of Infective Diseases and Public Health,
Università Politecnica delle Marche, Ancona, Italy | Departamento de Estomatologia, Universidad de Sevilla,
Spain
Note: [] Address for correspondence: Dr. Maurizio Battino, PhD, DSc,
Institute of Biochemistry, Faculty of Medicine, Università Politecnica delle
Marche, Via Ranieri, 65, 60100 Ancona, Italy. Tel. +39 071 2204646; Fax: +39
071 2204398; E-mail: [email protected]
Abstract: Cyclosporine A (CsA) plays a pivotal role in controlling
Ca^{2+}movement in the cell modulating also the
mitochondrial permeability transition pore. We investigated if chronic
administration of CsA may have some effects on the lipophilic and hydrophilic
antioxidant pattern of rat liver mitochondria and on their morphological
structure. It seems that CsA administration does not statistically affect the
redox status of the antioxidants investigated and their amounts (vitamin E,
CoQ_9, CoQ_{10}, glutathione,uric acid
and ascorbic acid) despite the variety of effects that this treatment produces
at physiological and morphological levels. However, some kind of derangement
could occur in the liver biochemical machinery since CsA treatment induces a
markedly increased variability in antioxidant contents.
Keywords: coenzyme Q, Vitamin E, rat liver mitochondria, GSH, uric acid, ascorbic acid
Journal: BioFactors, vol. 18, no. 1-4, pp. 271-275, 2003
