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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: The flow in the axial plasmatic gaps of the smaller vessels of the microcirculation has been studied by numerical solution of the creeping flow equations in a simplified model of the capillaries. Stream functions, velocity distributions, pressure drops and circulation times have been obtained for three axisymmetric configurations: erythrocytes spanning the entire lumen, with erythrocyte-plasma interface straight (Model A) and curved (Model B) and erythrocytes spanning only a portion of the lumen, with straight interface (Model C). The results for Model A have also been compared with those for the corresponding two-dimensional case. The most important finding is that the…circulation pattern in the spaces between erythrocytes is of primary importance in determining the pressure drop, but can have only limited influence on the oxygen and heat transfer processes in a capillary.
Abstract: The influence of external stress on the hydrothermal and chemical (induced by water solutions of KCNS and HCl) contraction of native collagen fibres has been investigated. The experiments were made in the isometric and isotonic measurements modes. The coincidence of isometric and isotonic data permits the consideration of a certain portion of the isometric curve as a phase equilibrium curve similar to the pressure-temperature curves of phase equilibrium for the low molecular weight substances. The existence of a certain critical tension and of a corresponding critical temperature in the case of hydrothermal contraction and of a critical composition of environment…in the case of chemical contraction was suggested, and their values were calculated for the systems under consideration. Thermodynamic calculation gives us an estimate of the enthalpy of melting Δ H u = 2.12 ± 0.3 kcal/mole of peptide units in the case of hydrothermal contraction and correspondingly of a certain “enrichment of salt” Δ ϵ = 4.6 · 10 − 2 moles KCNS/mole of aminoacid units in the case of KCNS-contraction. The cooperativity parameters for both processes were estimated, and their order was found to be 10−4 The nature of the transition occurring is discussed in terms of the general theory of order-disorder transitions in unidimensional ordered systems. The conclusions drawn are confirmed by X-ray evidence.
Abstract: A capillary instrument is developed for the measurement of the viscoelastic properties of biological fluids, such as saliva and mucus. With the instrument developed, the recoil is measured as a function of applied pressure, enabling one to calculate such important rheological properties as the non-Newtonian viscosity and the elastic shear modulus. In order to determine the reliability of the instrument, a series of measurements were made on a 3% polyisobutylene solution in decalin and the measured values of recoil and viscosity were found to be in very close agreement with those obtained by other instruments (cone-and-plate instrument and flow birefringence).…Further measurements were then made on several samples of biological fluids (egg white, saliva, and lung mucus). The results are very encouraging and the method promises a wide application to the characterization of other biological fluids.