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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Neointimal hyperplasia influenced by intravascular hemodynamics is considered partly responsible for restenosis after endovascular stenting. To evaluate the effect of stent configuration on fluid flow behavior, we visualized flow near stents, and measured the proliferation of cultured endothelial cells (ECs). A single‐coil stent (coil pitch; CP=2.5, 5, or 10 mm) was inserted into a glass tube and perfused at 30–90 ml/min, while the flow pattern was determined by particle imaging velocimetry. The reduction of the flow velocity near the wall was correlated with the decrease in the coil interval of the stent. In perfusion cultures with stents, the proliferation of…ECs was influenced by the local flow velocity distribution. When a stent with a CP value of 10 mm was used, the doubling time of ECs was 30.7 h, while the doubling time was 38.5 h when the CP was 5 mm. The doubling time of ECs was shorter at sites upstream of the stent wire where the velocity was higher than downstream of the wire. In conclusion, a single‐coil stent can be used to modify hemodynamic factors, suggesting that improved stent design may facilitate rapid endothelialization after stent implantation.
Abstract: Computer modeling is becoming increasingly important in the realm of brain biomechanics and injury. New computer simulations range from modeling of brain surgery, a low frequency, high strain event, to predicting injury as a result of an impact to the head, a high frequency event with varying strain magnitudes. This range of modeling efforts requires characterization of the tissue over as wide a frequency and strain range as possible. Research done to date has concentrated on the low frequency properties of the tissue. Complex compression and complex shear moduli have been measured at frequencies up to 350 Hz. Impact modeling…requires use of frequency data at significantly higher frequencies than these. The “wave‐in‐a‐tube” ultrasonic method was applied to brain tissue to determine mechanical properties at frequencies between 100 kHz and 10 MHz. Of these properties, only complex bulk modulus |K* | is fairly invariant (2133 MPa) with respect to frequency. Complex shear and complex Young's moduli vary with frequency and approach an asymptotic upper limit. Some variation in complex Poisson's ratio was also observed.
Abstract: The present study investigates the flow effects that different blood constitutive equations induce when employed in numerical simulations in the framework of computational hemodynamics. In accord with experimental studies on the rheological behavior of blood, three blood constitutive equations namely the Casson, Power‐Law and Quemada models were used for simulating the shear flow behavior of blood. The case studied is the flow in a channel with a moving part of the boundary and was selected because it reproduces the flow phenomena occurring in realistic arterial conditions. Flow simulation for every model is carried out assuming the same flow rate at…the inlet of the channel and different Strouhal numbers reflecting different intensities of the boundary movement. Results show that the modeling of blood as non‐Newtonian fluid has marked qualitative and quantitative effects on both the flow field and the wall shear stress whereas comparison of the different models shows good agreement between the flow effects by the Casson and Quemada models.