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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: We re-examined the measurement of the mass flow ratio at model bifurcations as a function of the inlet Reynolds number, which has been used to study the role of arterial bifurcation in distal blood supply. However, this relationship was found not to be applicable to investigations of blood circulation, because the measured mass flow ratio is strongly dependent on the resistance downstream of the bifurcation, and therefore is specific to the experimental set-up. An alternative approach for studying the role of arterial bifurcation is presented, in which the flow division ratio is used as a parameter.
Abstract: Although a decrease in the deformability of red blood cells (RBCs) has been suspected in Heinz body-forming hemolytic anemia, it remains uncertain whether the formation of Heinz bodies themselves impairs RBC deformability or not. To elucidate this question, we used RBCs treated with phenylhydrazine and RBCs from patients with unstable hemoglobin (Hb) disease (Hb Yokohama) to investigate the effect of Heinz body formation on deformability in terms of RBC filterability through nickel mesh and viscosity of the RBC suspension. The phenylhydrazine-treated RBCs exhibited a marked decrease in deformability in a dose-dependent manner. The Heinz body-forming RBCs from the patients also…showed a marked decrease in deformability. Thus we confirmed that Heinz body formation impairs RBC de formability. Further, both phenylhydrazine-treated RBCs and RBCs from the patient showed a degradation of spectrin without any cross-linking of membrane proteins, thereby suggesting that the impaired deformability is associated with the oxidative degradation of the cytoskeletal framework. In summary, this study supports the conclusion that RBC deformability is impaired by the presence of Heinz bodies as well as the related oxidative damage involved in their formation.
Abstract: Flow characteristics are examined in two lateral model aneurysms by means of numerical simulation. The study concentrates on basic flow and stress patterns in a rigid wall and in a distensible wall aneurysm. The numerical solution of the governing Navier-Stokes equations describing incompressible, pulsatile, three-dimensional non-Newtonian flow is accomplished with the use of a finite element method together with a pressure correction technique. The inflow into the aneurysm is seen to arise from the downstream lip of the orifice and to be directed backward to the center. Backflow to the parent vessel takes place along the walls of the aneurysm.…The intra-aneurysmal flow is found to be low compared with the flow velocity in the parent vessel, and even stagnation of flow occurs in the dome of the aneurysm. With a distensible wall, the basic flow characteristics are changed during systolic flow. The intra-aneurysmal secondary flow increases significantly. The increase and decrease of the flow velocity at the downstream lip reflect the expansion and contraction of the aneurysm wall where the maximal wall displacement during systolic acceleration is about 6% of the aneurysm diameter.