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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Perihemorheology concerns the rheology of fluids and structures in the perivascular spaces. Furthermore, the term refers to the exchanges of rheological processes between the vessel-blood organ and its surrounding tissues, as well as in reverse. In 1960, the vessel wall and the circulating blood were considered by the author as an entity which in 1981 he postulated as an organ, named the ‘vessel-blood organ’, penetrating all other organs. This communication is not a survey but is intended to stimulate biomedical thinking regarding the importance of perihemorheology. The significance of the endoendothelial fibrin(ogenin) lining (EEFL) and fibrin(ogenin) as constituent of the…interendothelial cement and the basement membrane in relation to perihemorheology is stressed. The role of albumin in the exchanges between hemorheology and perihemorheology is discussed. The protein content, as found by Witte, in the perivascular spaces as compared to the blood is emphasized regarding the importance of interrelations between the vessel-blood organ and rheological processes in the perivascular spaces. Recent studies, particularly by Laurent and his group, pertaining to hyaluronan in perivascular spaces and the blood demonstrate also the importance of the interrelationship between hemorheology and perihemorheology. The term ‘blood-brain barrier’, considered no longer to be adequate, is replaced by the term ‘basement membrane-brain barrier’. It is proposed that the basement membrane of the vessel-blood organ penetrating the brain may contain certain constituents, unknown thus far, and may have a different structure from the basement membrane of the vessel-blood organ penetrating organs other than the brain.
Abstract: Electrokinetic measurements and rheological studies conducted in parallel have previously shown red cell surface charge to play a role in governing aggregative behavior and bulk flow properties of red cell suspensions. For these and other types of model investigations, aldehyde stabilized cells have been widely used. In this communication, the influence of the purity of formaldehyde was investigated. It was found that (a) the direct dissolution of commercially available paraformaldehyde in water or suitably buffered saline results in impure solutions which, if utilized in the fixation of human erythrocytes, produces cells which have significantly different electrophoretic properties from native cells;…(b) the basis for the differences is the presence of metallic impurities in some commercially available paraformaldehyde preparations; (c) the impurities and thus the anomalous electrokinetic properties of the fixed cells may be eliminated by generating formaldehyde gas from paraformaldehyde by heating the latter to 203–210°C; (d) alternatively, the impurities may be eliminated by addition of disodium ethylenediamine tetraacetate dihydrate to fixative solutions prepared directly from paraformaldehyde.
Abstract: The steady flow viscosity at shear rates 0 to 120 sec−1 and dynamic viscoelasticity at frequencies 0.02 to 0.8 Hz were determined for aqueous suspensions of uniform polystyrene microspheres of 1.0 μ m diameter. Rheological properties of the microsphere suspensions were Newtonian for particle concentrations up to 32%. By introducing dextran and calcium chloride into the particle suspensions, non-Newtonian behavior was produced similar to that observed for human blood. The cooperative effects of dextran and calcium ions promoted aggregation of particles at a concentration as low as 12%. Thus, a suspension of uniform sized spherical polystyrene particles in aqueous…solution of dextran may be made to mimic blood by controlling the surface charge on the polystyrene spheres using addition of calcium ions to the medium.