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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Since the sweet ketohexose L-sorbose causes overt hemolysis in dogs but not in man, we examined the possibility that L-sorbose induces a “prehemolytic state” of human red cells, manifesting itself as impairment of rheological red cell properties. After 2 hours incubation at 37°C relative viscosity of red cell suspensions measured by radial spreading in filter paper and packing ability of red cells were normal. Incubation for 24 and 48 hours of red cells in media containing L-sorbose, glucose or no sugar showed that relative viscosity was best maintained in glucose. Relative viscosity and packing ability of red cells in L-sorbose…containing suspensions decreased less than in suspensions without sugar. This difference was independent of the glucose metabolism, red cell ATP, osmolality and pH of the suspending media, but appeared to be related to different degrees of spheroechinocytic red cell shape transformation observed in different suspending media. It is possible that L-sorbose has some antiechinocytic properties and/or that it induces an alteration of red cell membrane flexibility. There is no indication of an I.-sorbose induced “prehemolytic state” in human red cells.
Keywords: Red cells, viscosity, shape, packing ability, L-sorbose
vol. 22, no. 3, pp. 175-184, 1985
Abstract: The aggregation behaviour of normal and heat treated (48.4°C, 48.8°C, 49.5°C) red blood cells (RBCs) suspended in dextran-saline solutions (Dx70, Dx173) was investigated by a laser light reflectometric method over a wide range of bridging energies. The characteristic times of rouleau formation were found to be increased after RBC heat treatment. The disaggregation shear stress is not significantly different between normal RBCs and heat treated RBCs. The loss of cell deformability is nevertheless shown to improve slightly the dissociation efficiency of the flowing liquid in a shear flow resulting in a small reduction of the disaggregation shear rate after heat…treatment. Heat treatment is also shown to alter the structure of RBC network at equilibrium. These results indicate that heat induced alterations of erythrocytes only affects the mechanical properties of the cell membrane without significant changes in the macromolecular bridging energy.
Abstract: In order to attempt in vitro evaluation of antithrombogenecity for materials of artificial blood vessel tube, a new type of rheometer was developed. The rheometer originally consists of a cylindrical tube suspended from a torsion wire and filled with blood. The tube is excited in torsional oscillation and subsequent damped oscillation is observed. The apparatus can sensitively follow the change of fluidity during coagulation of blood. The damped oscillation curves during coagulation for fibrinogen-thrombin solution and blood put in a cylindrical tube made of the artificial material were measured. For fibrinogen-thrombin solution with lower fibrinogen and thrombin concentrations, the values…of logarithmic damping factor (LDF) during coagulation increased and then decreased through a maximum. For blood and fibrinogen-thrombin solution with the higher concentrations of fibrinogen and thrombin, LDF monotonously decreased with the progress of coagulation. With a glass tube, the decrease of LDF for whole blood taken without anticoagulant rapidly occurred within about 15 min after sampling, while, with expanded poly tetrafluoroethylene (EPTFE ; Goar tex® ) and polydimethylsiloxane (Silastic® ) tubes, the decrease of LDF proceeds over 40–60 min. The present method is probably available for in vitro evaluation of anticoagulability or antithrombogenecity of artificial materials.
Abstract: The viscoelastic behaviour of hardened or aggregated red blood cells is compared with the flow pattern of native red blood cells, all suspended in buffer solution at a hematocrit of 45%. The rheological properties are investigated under oscillatory shear at the constant frequency of 2Hz. Variation of the amplitude covers a range of shear-rates from 0.5/s to 200/s. It can be seen that rigidification of the red cells by treatment with glutardialdehyde leads to changes of the flow properties in the range of shear-rates above 10/s, whereas aggregate formation due to addition of dextran distinctly alters the flow properties in…the range of shear-rates below 10/s.
Abstract: The fluorescence polarization of probe molecules gives information on the “fluidity” of probe environment. Although the data cannot be related with absolute values of microviscosity, the method is largely used for probing the “fluidity” of lipid regions of biological membranes. Therefore, fluorescence polarization is of interest in clinical research, for membrane alterations are associated with either pathological processes of red cells, platelets, leukocytes or important cell functions.