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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: When a suspension of erythrocytes labeled in their membrane with a fatty acid paramagnetic molecule is allowed to flow in a flat quartz sample cell, the recorded electron paramagnetic spectra change as a function of the orientation of the cell in the magnetic field. This indicates that the red cells are themselves oriented in the flow. Such spectral variations have been reproduced by a numerical simulation procedure, which allowed us to quantify the proportion of oriented red blood cells by measuring the amplitude of sone characteristic lines on the experimental spectra. Orientation rates were then measured as a function of…various rheological parameters, such as shear rate, hematocrit and viscosity of the suspending medium. The kinetics of the disorientation process was determined by stopping the flow.
Keywords: Spin label, Erythrocyte orientation
vol. 19, no. 6, pp. 669-680, 1982
Abstract: The flow within a concentric cylinder viscometer is analysed theoretically. A model for the whole blood is developed which takes account of the plastic properties of blood together with the effect of red cell migration. The results of the analysis indicate the possibility of a solid and liquid phase co-existing in the viscometer at sufficiently low shear rates. The effect of the migration of deformable aggregates within the blood away from solid boundaries is also considered and a correction technique for experiments is suggested.
vol. 19, no. 6, pp. 681-694, 1982
Abstract: Dynamic mechanical measurements were carried out to clarify the mechanism of the clotting process of casein micelle solution. It was found that the clotting process of casein micelle solution was formally expressed by a first order reaction. The enzyme concentration dependence of the latent time tL and the rate constant of gelation Kg were found to be tL ∞ [E]−1.1 and Kg ∞ [E]1.0 , respectively. These results were interpreted on the basis of the theory of gelation. The results obtained here were found to agree with the theoretical conjectures. The casein micelle concentration dependence of…the complex rigidity was also studied.
Abstract: Most of the physiological fluids are transported through peristalsis of the walls which is the inherent neuromuscular property of tube smooth muscle structure. The present paper deals with the transport of seminal fluid introducing the microstructural effects and peripheral-layer viscosity effects on the flow rate and the drag for the system. It has been Observed that the flow rate increases tremendously with the decrease of the peripheral layer viscosity whereas a reverse trend has been noted for the frictional drag. Further other sub-structural effects i.e. the effects of relative rotational viscosity and Viscosity gradients have also been broughtout and discussed.
Keywords: Seminal Fluid, Micro-structural effects
vol. 19, no. 6, pp. 707-715, 1982
Abstract: Interactions among red cells and platelets in flowing blood result in significant dispersive motions of the platelets, which are commonly modelled by an effective diffusion coefficient. This paper examines an additional platelet flux, termed rheophoresis, to model platelet motions due to the gradient of hematocrit. Rheophoretic effects occur near walls because geometric exclusion and fluid mechanical repulsion of red cells create a hematocrit gradient there. Models using rheophoretic flux show that platelet concentration near walls is elevated; such models provide a consistent interpretation of available experimental data. Estimates show the coefficients for traditional effective diffusivity and the rheophoretic diffusivity have…similar magnitudes. The effects of rheophoresis on axial development of platelet concentration profiles and on surface deposition are discussed.
Abstract: The SER allows the “deformability” of individual red blood cells to be quantitated by determining their passage time through a pore (d=5.8 μ m, 1 =50 μ m) under the shear stresses of 1.5 Pa-4 Pa. Using this system, we examined the influence of: 1. cytoplasmic viscosity, 2. membrane viscoelastic properties, 3. area to volume relationship. To change these determinants of RBC-deformability, the cells have been altered with 1. Acetylphenylhydrazine (0.016 mol/l), 2.diamide (0.5 mmol/l), 3. osmotic swelling (200 mosm/l) and osmotic shrinking (480 mosm/l) by suspending the cells in hypo- and hypertonic saline. The passage time has been found…to be primarily influenced by changes in cytoplasmic viscosity. The same cells when tested in 4 other systems considered to measure RBC-deformability (filtrometer, packed cell viscometry, rheoscope and ektacytometry) behaved differently.