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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: Dextran was used to induce rouleau formation of heat-treated (48.80C) and normal human red cells. The microscopic aggregation index and the shear stress required for rouleau dissociation in a parallel-plate flow channel were not affected by heat treatment. The electrophoretic mobility and surface dextran adsorption of heat-treated cells were also normal. These findings indicate that the heat induced alterations in the endoface membrane proteins do not have a significant influence on red cell aggregation by dextrans which bridge the exoface membranes of adjacent cells. The reduced membrane deformability of the heat-treated red cells leads to a lesser change in the…curvature of the end cells in the rouleaux in response to a given alteration in membrane strain energy due to cell aggregation.
Abstract: A novel technique was used to measure wall shear stress in a glass model of an aorto-renal bifurcation. A viscous, white coating material was applied in a thin layer to the inner walls of glass models, and the removal of the layer by steady flow of a dark aqueous dye (Reynolds number 510 and 1000) was recorded on videotape. On playback, a video analyzer produced intensity versus time information at chosen positions. In a calibration experiment using Poiseuille flow, the inverse of the time between 50% and 20% of the total intensity change was linearly related to the calculated wall…shear stress (correlation coefficient 0.98, range tested: 0 to 4 dyn/cm2 ). Measurements were made at 36 positions downstream from the side branch in a 90°-side branch model (main branch and parent = 1.56 cm I.D., side branch = 0.77 cm I.D.) of a renal bifurcation. As anticipated, there was a high shear stress region downstream from the branch but this region had a bilobate shape that was not expected. Similarity principles were used to convert wall shear stresses measured in the model to those which would occur with blood flow. Results indicate that in vivo shear stresses near a bifurcation exceed those reported to cause changes in endothelial cell permeability, and in some cases reach values reported to cause structural damage to endothelial cells.
Abstract: The network structure of fibrin clots formed under various conditions was investigated using rheological and morphological techniques. The diameter of fibrin fiber is greatly dependent on the ionic strength of the fibrinogen-thrombin solution. The crosslink reaction between fibrin fibers is followed by the lateral association around the crosslinked regions. At low and high ionic strengths (μ < 0.2 and μ > 1.5) the fibrin fibers are thick and the lateral association of fibrin fibers hardly takes place, but at middle ionic strength (μ = 0.5 ∼ 1.0), the fibrin fibers are thin and the lateral association of…fibrin fibers easily occurs. At middle ionic strength, the increase of pH and the increase of the concentrations of fibrinogen and thrombin both results in the decrease of lateral association.