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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: This paper is concerned with the optical properties of suspensions of blood cells subjected to flow, under conditions where rates of shear are non-uniform and undefined, as for stirred or swirled suspensions, or where they are rigorously defined, as for suspensions flowing between counter-rotating glass discs in a microCouette device. A detailed example of each of these two types of investigations is presented: (i) the determination of light transmission constants of suspensions of blood cells as a function of particle concentration, particle shape and stirring rate with a platelet aggregometer. This device measures light transmittance in suspensions contained in a…cylindrical cuvette maintained at 37’C and stirred with a magnetic bar. Both light transmission and associated stirring-dependent scintillations are related directly to the particle shape and pharmacologically-induced shape changes, as well as aggregation; (ii) the measurement of the period of damping and associated relaxation time of the rheo-optical transients observed for dilute suspensions of erythrocytes subjected to Couette flow. These are shown to be quantitatively related to particle geometry and particle interactions in terms of theoretically-derived rheological parameters. Other related rheo-optical methods are compared with these two specific examples, and summarized in terms of the optical parameters studied and the associated suspension or particle property being described for erythrocytes and platelets. It is seen that particle concentration, volume, shape and state of aggregation can generally be measured, depending on the parameters being analyzed. Shear-dependent scintillations or transient oscillations are found to reflect essentially the asymmetric shape of cells. The advantages and limitations of these different methods are presented. Finally, the future possible directions of rheo-optical studies are indicated.
vol. 12, no. 3-4, pp. 193-202, 1975