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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: This study deals with blood viscosity factors not usually employed in the biorheological characterization of disease or as prognostic indices, The apparent viscosity of artificial red/white and white thrombi and aggregation of red cells, as defined by the erythrocyte sedimentation rates corrected for plasma viscosity and adjusted to haematocrit of 30 per cent, arc elevated in cardiovascular diseases, such as myocardial infarction and renal failure, and in malignant melanoma. The two new potential diagnostic or prognostic parameters studied are: (a) influence of fibrinogen level on the apparent viscosity of artificial thrombi and on the aggregation of red cells; and (b)…influence of ABO blood groups on the correlations obtained for the functions described under (a). It is shown that the effect of fibrinogen varies greatly depending not only on the type of disease but also on the type of ABO blood group. While in the normal states or in artificial systems the levels of fibrinogen arc correlated with the increases in these rheological parameters, there is no correlation in vascular disorders. In all the vascular and malignant disorders there were very significant (P < 0.001) differences between A and O, A and B, and Band O blood groups in the effects of fibrinogen level on these rheological functions.
vol. 10, no. 4, pp. 585-594, 1973
Abstract: Vessels in the microcirculation have been compared to channels in a gel. In this study a method has been developed whereby a geometrically well defined section of a flow system was composed of a cylindrical gel mantic of outer radius R G , surrounding a cylindrical channel of radius R . Both the channel and the mantle were of length L and were contained in a rigid transparent support of inner radius R G . Hence R G and L were fixed (R G = 1.3 or 4.5 mm; L =…40 mm) and the radius R ≃ 0.14 mm could be measured by mounting the whole system on the stage of a microscope fitted with an eye-piece micrometer. The gel was crosslinked polyacrylamide swollen with water. Water also served as the flow medium. It was found that R increased with absolute pressure applied statically to the system under no flow conditions. In flow the channel tended to expand upstream and contract down stream. Flow rate Q through the system and pressure drop ΔP were measured and the radius of the channel was monitored as a function of distance x along its length. At low pressure gradients now rates Q agreed with the theoretically predicted flow rates Q o but dropped below Q o at higher pressure gradients even though allowance was made for changes in R in calculating Q o and flow was shown to be laminar. The extent of the deviation decreased with gel rigidity G ′ and increased with thickness of the gel wall R G − R . The results expressed as Q /Q o could be correlated when plotted as a function of α = ( R G / 2 L G ′ ) Δ P , and corresponded approximately to the function Q / Q o = ( 1 − α ) 4 . The relevance of these results for the microcirculation is discussed.
vol. 10, no. 4, pp. 595-604, 1973