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Daily rhythm of salivary IL-1ß, cortisol and melatonin in day and night workers

Issue title: IEA 2012: 18th World congress on Ergonomics - Designing a sustainable future

Article type: Research Article

Authors: Reinhardt, Érica Lui; | Fernandes, Pedro Augusto Carlos Magno | Markus, Regina Pekelmann | Fischer, Frida Marina

Affiliations: Dept Environmental Health, School, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715, 01246-904, São Paulo, SP, Brazil | Occupational Hygiene Division, Fundacentro, R. Capote Valente, 710, 05409-002, São Paulo, SP, Brazil | Department of Physiology, Biosciences Institute, University of São Paulo, R. do Matão, Travessa 14, São Paulo, SP, Brazil

Note: [] Corresponding author. E-mail: [email protected]

Keywords: shiftwork, cytokines, biological rhythms

DOI: 10.3233/WOR-2012-0952-5788

Journal: Work, vol. 41, no. Supplement 1, pp. 5788-5790, 2012

Published: 2012
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Abstract

Shiftwork-induced sleep deprivation and circadian disruption probably leads to an increase in the production of cytokines and dysregulation of innate immune system, respectively. This project aims evaluating changes in salivary IL-1 beta, cortisol, and melatonin in night workers. Method. Two day and three night healthy workers participated in this study. Sleep was evaluated by actimetry and activity protocols. Saliva was collected at waking and bedtime the last workday and the following two days-off and was analyzed by ELISA. Results. Neither sleep duration nor efficiency showed any association with salivary IL-1beta. IL-1beta levels were higher at waking than at bedtime during working days for all workers, but only one day and one night-worker maintained this pattern and hormone rhythms during days off. For this night worker, melatonin levels were shifted to daytime. A second one presented clear alterations in IL-1beta and hormone rhythms on days-off. Conclusions. Our preliminary results suggest that night work can disturb the variation pattern of salivary IL-1beta. No association of this variation with sleep was observed. It seems that disruption in hormone rhythms interfere with salivary IL-1beta production. IL- 1beta production pattern seems to be maintained when rhythms are present, in spite of a shift in melatonin secretion.

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