Oxidation of indolic bases by cytochrome P450 and ferrous picolinate

Article type: Research Article

Authors: Jankowski, K.^; | Delaforge, M. | Jaouen, M. | Virelizier, H.^;

Affiliations: Faculté des Études Supérieures et de la Recherche, Université de Moncton, Moncton, N.‐B., E1A 3E9, Canada | Université René Descartes, URA 400 CNRS, 75270 Paris, France | Faculté des Études Supérieures et de la Recherche, Université de Moncton, Moncton, N.‐B., E1A 3E9, Canada

Note: [] To whom all inquiries should be addressed.

Note: [] Permanent address: CEN Saclay, SAIS, bât. 391, B.P. 2, 91191 Gif-sur-Yvette, France.

Abstract: Oxidations performed on four indolic bases, \beta‐carboline {\underline 1}, ibogaine {\underline 2}, reserpine {\underline 3} and ajmaline {\underline 4}, by hepatic cytochrome P450 (Cyt. P450) and ferrous picolinate (Fe(PA)2), lead to alicyclic hydroxylation as major reaction products.

Journal: Spectroscopy, vol. 13, no. 2, pp. 163-174, 1997