Preliminary study on the synthesis and high‐resolution NMR analysis of Naproxen and Ibuprofen esters

Article type: Research Article

Authors: Jankowski, Christopher K.^; | LeClair, Gaetan | Aumélas, André | Gonzalez‐de la Parra, Mario | Jimenez‐Estrada, Manuel | Tejada, Veronica | Chilpa‐Reyes, Ricardo | Bélanger, Jacqueline M.R. | Paré, J.R. Jocelyn

Affiliations: Département de Chimie et Biochimie, Université de Moncton, Moncton, NB, E1A 3E9, Canada | Instituto de Quimica and Departamento de Farmacia, Faculdad de Quimica, UNAM, Cd. Universitaria Circuito Exterior, 04510 Mexico, DF, Mexico | Microwave‐Assisted Process Division, Environment Canada, Ottawa, ON, K1A 0H3, Canada

Note: [] Corresponding author. E‐mail: [email protected].

Abstract: The synthesis and NMR analysis of several diastereoisomeric Naproxyl–Naproxenate, Naproxyl–Ibuprofenate and Ibuprofyl–Naproxenate esters are reported. The NMR high resolution spectra run in presence of the chiral shift reagents and variable temperature analysis were done to study the dynamic properties of these esters.

Keywords: Anti‐inflammatory, ester, NSAID, variable temperature NMR spectroscopy, shift reagent NMR and molecular modelling

Journal: Spectroscopy, vol. 18, no. 3, pp. 485-500, 2004