Affiliations: Department of Medical Engineering, National Defense Medical College, 3‐2 Namiki, Tokorozawa, Saitama 359‐8513, Japan | Department of Applied Physics and Physico‐Informatics, the Faculty of Science and Technology, Keio University, 3‐14‐1 Hiyoshi, Kohoku‐ku, Yokohama, Kanagawa 223‐8522, Japan | First Department of Anatomy, National Defense Medical College, 3‐2 Namiki, Tokorozawa, Saitama 359‐8513, Japan
Note: [] Corresponding author: Yuji Morimoto, MD, PhD, Department of Medical Engineering, National Defense Medical College, 3‐2 Namiki, Tokorozawa, Saitama 359‐8513, Japan. Fax: +81 42 996 5199; E‐mail: [email protected].
Abstract: We investigated the differences in Fourier transform‐infrared (FT‐IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU‐1, and NCI‐N87) showed a significant increase in infrared absorption in the band around 1240 cm−1, 1120 cm−1 and 1080 cm−1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm−1 and 3.8 cm−1 were seen at the peak absorbance in the bands around 1240 cm−1 and 1080 cm−1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT‐IR spectroscopy is a potential new tool for gastric cancer diagnosis.
Journal: Spectroscopy, vol. 18, no. 1, pp. 59-66, 2004
