Effect of highly concentrated gels of sodium hyaluronate on early phases of regeneration in the transected and tubulized rat sciatic nerve

Article type: Short Communication

Authors: Tona, Alessandro^; | Perides, George

Affiliations: Department of Pathology, Harvard Medical School and Spinal Cord Injury Research Laboratory, Department of Veterans Affairs Medical Center, West Roxbury, MA 02132 (USA) | Advanced Technology Division, Fidia S.p.A., Abano Terme (Italy)

Note: [] Correspondence: G. Perides, Spinal Cord Injury Research Laboratory, Department of Veterans Affairs Medical Center, West Roxbury, MA 02132, USA. Fax: (1)(617) 469 4081.

Abstract: Silicone regeneration chambers prefilled with sodium hyaluronate (HA) gels of different molecular weight (MW) and at different concentrations were used to tubulize the transected rat sciatic nerve. After two weeks, the tissue cables bridging the severed nerve ends within the silicone tubes were examined. Low MW HA gels had no significant effect while high MW HA gels reduced the diameter of the growing bridges.

Keywords: Hyaluronate, Peripheral nerve regeneration, Rat sciatic nerve

DOI: 10.3233/RNN-1993-5205

Journal: Restorative Neurology and Neuroscience, vol. 5, no. 2, pp. 151-154, 1993