Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Chauhan, Neelima B.; ;
Affiliations: Neuroscience Research, Jesse Brown VA Medical Center, Chicago, IL, USA | Department of Pediatrics, University of Illinois at Chicago, IL, USA | Children's Hospital of the University of Illinois, Chicago, IL, USA
Note: [] Corresponding author: Neelima B. Chauhan, Ph.D., R&D (151), Jesse Brown VA Medical Center, 820 South Damen Avenue, Chicago, IL 60612, USA. Tel.: +1 312 569 7747; Fax: +1 312 569 8114; E-mail: [email protected]
Abstract: Traumatic brain injury (TBI) is a serious public health concern and a major cause of death and disability worldwide. Each year, an estimated 1.7 million Americans sustain TBI of which ~52,000 people die, ~275,000 people are hospitalized and 1,365,000 people are treated as emergency outpatients. Currently there are ~5.3 million Americans living with TBI. TBI is more of a disease process than of an event that is associated with immediate and long-term sensomotor, psychological and cognitive impairments. TBI is the best known established epigenetic risk factor for later development of neurodegenerative diseases and dementia. People sustaining TBI are ~4 times more likely to develop dementia at a later stage than people without TBI. Single brain injury is linked to later development of symptoms resembling Alzheimer's disease while repetitive brain injuries are linked to later development of chronic traumatic encephalopathy (CTE) and/or Dementia Pugilistica (DP). Furthermore, genetic background of ß-amyloid precursor protein (APP), Apolipoprotein E (ApoE), presenilin (PS) and neprilysin (NEP) genes is associated with exacerbation of neurodegenerative process after TBI. This review encompasses acute effects and chronic neurodegenerative consequences after TBI.
Keywords: Traumatic brain injury, traumatic axonal injury, chronic traumatic encephalopathy, dementia pugilistica, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, dementia
DOI: 10.3233/RNN-130354
Journal: Restorative Neurology and Neuroscience, vol. 32, no. 2, pp. 337-365, 2014
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]