Effectiveness of non-pharmacological rehabilitation interventions in pain management in patients with multiple sclerosis: Systematic review and meta-analysis

Article type: Review Article

Authors: Hadoush, Hikmat^{a; *} | Alawneh, Anoud^a | Kassab, Manal^b | Al-Wardat, Mohammad^c | Al-Jarrah, Muhammed^a

Affiliations: [a] Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan | [b] Department of Maternal and Child Health, Faculty of Nursing, Jordan University of Science and Technology, Irbid, Jordan | [c] Department of Allied Medical Sciences, Aqaba University of Technology, Aqaba, Jordan

Correspondence: [*] Address for correspondence: Hikmat Hadoush RPT, PhD., Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. Tel.: +962 0 2 7201000 / Ext: 26882; Fax: +962 0 2 7095123; E-mail: [email protected].

Abstract: BACKGROUND:Multiple sclerosis (MS) is a progressive inflammatory and autoimmune neurological disease caused by inflammation and demyelination of the central nervous system. Pain is a typical symptom of central nervous system demyelination, affecting 63% of adults with MS. Recently, the role of non-pharmacological pain management in patients is growing because the non-pharmacological interventions are considered safe, affordable, easy, and accessible. However, to date, no systematic reviews or meta-analyses have comprehensively examined the therapeutic effects of the variety of non-pharmacological therapeutic interventions in the management of pain in patients with MS. OBJECTIVE:The study aimed to conduct a systematic review with meta-analysis to assess the effectiveness of the non-pharmacological rehabilitation interventions in pain management in patients with MS. METHODS:A comprehensive search using PubMed, Cochrane, and Science Direct databases was performed and included all randomized controlled trials, randomized cross-over trials, and quasi-experimental trials assessing the effect of non-pharmacological interventions for managing pain in patients with MS. This study was conducted according to PRISMA guidelines of a systematic review and pair-wise meta-analysis. Meta-analyses were performed by calculating the standardized mean difference at a 95% confidence interval using Review Manager software. RESULTS:Twenty-nine papers were included in the systematic review, and only 22 of them were included in the meta-analysis. The pooled analysis showed a significant effect of neuromodulation and transcranial direct current stimulation on pain intensity reduction in patients with MS (SMD –0.51, 95% CI –0.51 to –0.09, P = 0.02), (SMD –0.67, 95% CI –1.18 to –0.16 P = 0.01), respectively. The analysis showed significant improvement in pain intensity in patient with MS after mind-body therapies (SMD –0.45, 95% CI –0.82 to –0.7, P = 0.02), mindfulness (SMD –0.55, 95% CI –0.96 to –0.14, P = 0.009), hypnosis (SMD –0.88, 95% CI –1.30 to –0.46, P = 0.0001), trigger point therapies (SMD –0.83, 95% CI –1.65 to –0.01, P = 0.05) and cognitive behavioral therapy (SMD –0.64, 95% CI –1.18 to –0.11, P = 0.02). However, there is no significant effect of relaxation therapy on pain reduction in patients with MS (SMD –0.82, 95% CI –1.94 to 0.31, P = 0.15). CONCLUSIONS:The results indicated that the majority of the non-pharmacological rehabilitation interventions showed potential therapeutic effects in reducing pain intensity in patients with MS.

Keywords: Multiple sclerosis, neurodegenerative diseases, pain, rehabilitation, non-pharmacological interventions, meta-analysis

DOI: 10.3233/NRE-210328

Journal: NeuroRehabilitation, vol. 50, no. 4, pp. 347-365, 2022