Structured guideline-based physiotherapy reduces difficulties in activities of daily living in Parkinson’s disease

1Introduction

Parkinson’s disease (PD) is a common age-related neurodegenerative disorder and its neuropathology is characterized by a selective loss of dopaminergic neurons (Cacabelos, 2017). Clinical presentations of PD motor and non-motor symptoms, wherein tremor, rigidity, bradykinesia/akinesia, and postural instability are considered cardinal signs (Balestrino & Schapira, 2020).

PD affects various aspects of life, including an ability to transfer and ambulate, which further results in a disability (Shulman, 2010). At some point, most of the PD patients start to experience difficulties in the execution of daily functional tasks. Consequently, physiotherapy is advised with an objective to maintain the patient’s independence, to maximise his/her safety and wellbeing, and to improve his/her performance of ADL, and to reduce secondary complications (Keus et al., 2014) (Tomlinson et al., 2014).

European Physiotherapy Guideline for Parkinson‘s Disease (EPGPD) includes recommendations on specific interventions and states core areas (gait, transfers, balance, manual activities, and physical capacity) for physiotherapy intervention with PD patients (Keus et al., 2014).

For example, treadmill training is recommended by EPGPD. However, although its effectiveness is proved in increasing gait speed, stride length, and cardiovascular endurance in patients with PD (Nadeau et al., 2014), this and other recommendations (e.g. tai chi) provided by the guideline might not be applicable in clinical practice. On one hand, it could be due to possible limitations related to specific intervention settings of and intervention provider, and on the other hand, patients with PD might present a wide range of functional difficulties that cannot be addressed by merely one type of intervention. Therefore, there is a need for evidence-based studies on the implementation of guidelines into physiotherapy interventions to obtain the best results in everyday life for people with PD. A need for more structured physical therapy programmes in PD patients has also been reported in the literature (Clarke et al., 2016).

Pazzaglia et al. have also conducted a study (Pazzaglia et al., 2020), where one study group received a conventional rehabilitation programme conducted according to the physiotherapy guidelines for PD patients by Royal Dutch Society for Physical Therapy (Koninklijk Nederlands Genootschap voor Fysiotherapie, i.e. KNGF Guidelines for physical therapy in PD patients, 2004). This study aimed to assess an overall improvement in selected outcome measures after a 6-week virtual reality rehabilitation programme in comparison to a conventional rehabilitation programme in patients with PD, not to specifically analyse the aspects related to structured guideline-based conventional physiotherapy.

The effectiveness of physiotherapy interventions is generally based on measures of quality of life as a whole, motor symptoms, balance, and gait outcomes (Radder et al., 2020). Patient‘s perception of the impact of an intervention on the performance of basic ADL has often remained discarded, though physiotherapists are encouraged to deliver a patient-centred care (Stevens et al., 2017).

The main aim of the study was to assess the benefit of a 2-month of supervised conventional physiotherapy intervention that incorporates EPGPD recommended core areas. We hypothesised that two month of structured guideline-based physiotherapy reduces patients reported difficulties in activities of daily living in Parkinson’s disease.

2Materials and methods

2.1Participants

Fifty patients from the PD epidemiological database (Kadastik-Eerme et al., 2018) of Tartu University Hospital were randomly contacted by telephone and were asked for the study participation (convenience sampling). The individuals willing to participate were invited to a meeting to examine their current neurological status, including the disease stage and severity. PD stage and severity were determined according to Movement Disorders Society Unified Parkinson‘s Disease Rating Scale (MDS-UPDRS) (Goetz et al., 2008) and Hoehn & Yahr Scale (HY) (Hoehn & Yahr, 1967) respectively. Neurological assessment was carried out by two movement disorders experts during baseline assessment. In addition, the participants were interviewed for their quality of life using the Estonian version of Parkinson’s Disease Questionnaire 39 (PDQ-39) (Krikmann et al., 2008) during the baseline assessment. All the participants used antiparkinsonian medications as instructed by their neurologist.

A total of 24 patients complying with subsequent inclusion criteria were assigned into either intervention group (IG, n = 12) or control group (CG, n = 12) using randomized blocked design (to assure equal number of both female and male participants in both groups). The inclusion criteria for this study were:

(1) a confirmed diagnosis of idiopathic PD (stages 1.5–3 on HY); (2) age > 60 years and < 80 years; (3) an ability to walk without an assistive device in the home setting; (4) absence of any other medical conditions that may affect gait or postural stability; (5) no physiotherapy intervention was received during the previous year; (6) an MMSE (Mini Mental State Examination) score above 24 (see Fig. 1).

Fig. 1

Flowchart of the sample collection and study design.

All the participants provided informed written consent and the study was carried out in compliance with the Helsinki declaration; the study protocol was approved by the Research Ethics Committee of University of Tartu and was registered on Tartu University’s Clinical Research Database (No. 12125) (ClinicalTrials.gov Identifier: NCT03568903). There were no drop-outs from the study. Table 1 illustrates the baseline characteristics of the study participants.

Table 1

Comparison of clinical and demographic characteristics of the participants at baseline

Variable	IG (n = 12, 7F/5M) Mean (SD)	CG (n = 12, 7F/5M) Mean (SD)	p value
Age, years	71.1 (4.2)	69.9 (5.1)	0.54
Disease duration, years	8.0 (6.9)	7.7 (5.4)	0.93
HY stage	2.2 (0.5)	2.3 (0.7)	0.93
MDS-UPDRS total score	62.2 (21.5)	60.4 (26.7)	0.86
PDQ_Si	25.85 (31.18)	22.22 (12.12)	0.67
MMSE score	28.0 (1.9)	27.2 (1.5)	0.24
Height, cm	165.1 (10.4)	166.6 (10.1)	0.72
Bodyweight, kg	72.8 (14.7)	78.1 (14.6)	0.39

IG: intervention group; CG: control group; F: female participants; M: male participants; SD: standard deviation; HY: Hoehn & Yahr Scale; MDS - UPDRS: Movement Disorders Society Unified Parkinson Disease Rating Scale; PDQ_Si: total score/single index according to Parkinson Disease Questionnaire (PDQ-39); MMSE: Mini Mental State Examination.

3Results

Baseline assessment revealed no differences between the groups in any of the assessments performed (See Table 1)

During the baseline assessment IG demonstrated a little higher level of patient-perceived difficulties in basic ADL compared to CG, although this difference was not statistically significant. After 2-months of physiotherapy sessions in small groups patient-perceived difficulties in basic ADL were reduced in IG. There were significant improvements in the total score and also median and average scores of ModPSFS. Main results of the study are summarized in Table 3.

Of note, when comparing the extent of change in patient-perceived difficulties in basic ADL (according to ModPSFS) at baseline and second assessment, significantly different results were evident –for example, group effect of change of ModPSFS total score was significant and large effect 1.6 (p = 0.002). Between groups, the difference in ModSPFS median score was also of the large effect of 1.04 (p = 0.024).

Post-intervention 10 of the participants in the IG group reported their health status to be improved, whereas 7 subjects from CG found it to have deteriorated. Of note, many participants failed to list the activities they find difficult and want to improve and rather expressed their concerns about poor sleep, poor vision, back pain, hand tremor, especially during the second assessment.

4Discussion

This study revealed that physiotherapy intervention that focuses briefly on different core areas as recommended by the standard guidelines, helped to reduce the patient reported difficulties of basic ADL in the PD patients.

We used a previously unused patient reported outcome measure ModPSFS, which is a combination of two standardized assessment measures, namely PSC and PSFS.

The PSC is one of the frequently used measuring instruments in Dutch community-based physiotherapy practices (Swinkels et al., 2011). Administration of PSC is also recommended by KNGF Guidelines for physical therapy in PD patients (2004), however, this instrument has hardly been used in research, especially with PD patients. During the administration of the original version of PSFS, a patient is expected to list any three (up to five) activities that are limited and for which he/she is seeking treatment. During reassessments, the patient is asked to provide a current difficulty score for the same listed activities (Beurskens et al., 1999). PSFS is claimed to be an easy-to-use valid, reliable, responsive, and efficient outcome measure applicable to a large number of clinical presentations, including in assessing physical function in community-dwelling elderly (Mathis et al., 2019). It has also been used in PD adults: The PSFS yields reliable scores when it is administered to people living with PD (Burgos-Martinez, 2011). Yet, though one part patient-centered physiotherapy is to clarify patients’ problems (Donnelly & Carswell, 2002), then measurement of physical function that is both specific to the individual and generates comparable outcome data is a fundamental need in physiotherapy examination (Mathis et al., 2019), which can be met by using ModPSFS.

Bohannon and co-authors revealed that patients with PD identified 60 different activities they were unable to do or they were experiencing difficulties as a result of their PD (Bohannon et al., 2020). Comparable outcome data is also of key importance in both research and clinical work. To compare the impact of an intervention on the basic ADL, standardized assessment, including the same specific activities, seems appropriate.

Previously used standardized assessments are the Nottingham Extended Activities of Daily Living (NEADL) Scale (Clarke et al., 2016) and Patient-Specific Index for Physiotherapy in Parkinson‘s disease (PSI-PD) (Nijkrake et al., 2009). Both include a list of pre-defined activities, analogous to ModPSFS. However, though both can be considered as good outcome measures of ADL from a patient’s perspective, they do not enable good comparisons across individuals or groups. For example, NEADL (Clarke et al., 2016) involves 22 questions on different activities which the subject is required to provide on one of four answer boxes for each keeping in mind the past week. However, it includes several activities that can remain un-executable due to other reasons not due to functional difficulties (for example gardening/driving a car because she or he does not own a garden or a car). Understandably, a valid comparison of two persons cannot be performed if one has provided one of the following ratings “with help”, “on my own with difficulty” or “on my own” for all 22 activities and another person has used the answer option “not at all” for several items.

PSI-PD (Nijkrake et al., 2009) includes an excellent predefined list of 26 aspects in which a person with PD is likely to experience limitations, however, PSI-PD also includes some items that the authors of the present study knew in advance that not all participants would perform (e.g. getting on or off a bicycle), we did not use the predefined list (though several items are included), but generated our list of 24 pre-defined activities, assumed to be performed on regular basis in person’s daily life. Participants were asked to rate and make a self-check if they perform the listed activity in their everyday life. To ensure that all the participants remain comparable, ModPSFS scoring was based only on 17 activities that each participant executed in his/her everyday life. For example, some male participants were not able to rate difficulties in food preparation as this was entirely the spouse’s responsibility in their household. Gender is likely to be one of the most evident contributors to the execution of ADL. Some gender differences in instrumental ADL in PD patients have also been reported previously (Foster, 2014).

The ModPSFS enables to obtain a perception of “the extent of the limitation/perceived difficulty” as the patient provides an answer on an 11-point VAS scale as in original PSC the severity for each complaint is scored (Beurskens et al., 1999) (‘0’ indicates, I do not experience any problems with this activity, while, ‘10’ indicates a situation where the patient is unable to perform the activity independently). PSI-PD provides an examiner with a list of limitations, assessed basically on a 2-point scale (e.g. item “turning around in bed” limited, “instability when stopping walking” –not limited), along with a ranking of “top five” activities that are limited items he or she wishes to improve. ModPSFS could be used to aid this along with a greater degree of comparison and generalization than is currently available from scientific evidence with PD patients, or a variety of other comorbidities and medical conditions. The validity and reliability of this test can hopefully be provided in near future.

In this study, 80%of the participants in the IG group reported post-intervention improvement health status, whereas nearly 60%of CG members perceived their health status to have deteriorated at the second assessment. This is a clear indication of the successful administration of patient-centred physiotherapy in PD patients.

A health status check was just a one-item question in ModPSFS. However, Rosenzveig et al. (2014) have reported that there is sufficient evidence to warrant the use of single items in clinical practice and also for long term monitoring (Rosenzveig et al., 2014). Despite that lack of time has been identified as one of the key barriers to patient-centred care (West et al., 2005), nonetheless, there should always be time to ask the patient to provide a one-item estimation on their health status, both pre- and post-intervention.

Clarke et al. (Clarke et al., 2016) reported the evidence on the usage of low-dose, patient-centred, goal-directed physiotherapy and occupational therapy in early stage PD patients to be insufficient. However, besides using NEADL as the main outcome measure (which might degrade comparison, as discussed earlier) the individualised interventions administered in Clarke et al. (Clarke et al., 2016) were for a very short period (median of four visits of 58 minutes as contact time), compared to 16 one-hour sessions in the present study.

Clarke et al. (2016) also indicated a need of more structured and intensive physical therapy programmes in PD patients. Our study, where versatile physiotherapy involving the core areas as recommended in EPGPD (Keus et al., 2014) is an example of such intervention.

Conventional rehabilitation programme claiming to be conducted according to the physiotherapy guidelines have been published earlier, e.g. a study by Pazzaglia et al. (2020) who based the intervention of one of the study groups on KNGF (2004) for PD. Interventions in Pazzaglia et al. (2020) and our study cannot be directly compared, as they differed substantially in many aspects (e.g. duration of intervention session and period). Nevertheless, Pazzaglia et al. (2020) reported that both interventions provided in their study, virtual reality therapy and conventional physiotherapy intervention, resulted in a significant improvement in arm function. Arm function improvement has a significant impact on the performance of daily activities. Though upper limb functional assessment was not included in our study, likely, incorporation of 10 minutes of manual activities into the therapy sessions has contributed for a reduction in perceived difficulties in basic ADL (by improving arm function).

Besides a 10-minute section of manual activities, the physiotherapy session included 4 other sections to address other core areas on EPGPD. Still, it is possible, that 60-minute sessions as designed in this study, may not be sufficient to focus in the best possible way on each core area recommended in EPGPD. For example, not all aspects of physical capacity, which is defined as including exercise tolerance and endurance along with joint mobility, muscle tone, power, and coordination in EPGPD (Keus et al., 2014), received the optimal attention in the present study. Specifically, the aspect of endurance and exercise tolerance was not focused extensively in this study, though a fixed period focusing strictly on this aspect of physical capacity would have been relevant. In order not to exhaust the patient during supervised sessions, the exercise tolerance aspect was diminished in the present study, as it could be more easily addressed in a form of unsupervised activities between sessions. However, other aspects of physical capacity were included. Further research should be undertaken to investigate which is the optimal length of intervention targeted to each of the core areas recommended in EPGPD. We propose that further research should take place to optimize intervention duration targeted to each core area recommended in EPGPD.

The recommendations from the EPGPD guideline were incorporated into group physiotherapy intervention instead of individualised intervention, which might somewhat influence the results. Administration of conventional physiotherapy in a group environment has been reported influential to improve attitude and foster optimism among PD patients (Park et al., 2014). We considered a group of 3–4 people to be optimal to bring out positive aspects of group therapy and at the same time to keep a necessary individualized approach for the patient to be cost-effective. Our approach of providing ‘conventional physiotherapy’ as group treatment is well supported by EPGPD (Keus et al., 2014).

The number of patients enrolled in the study is relatively small, which can limit the extrapolation of the study outcomes in the larger population. Hence, we were conservative in the interpretation of the results and while concluding.

The participants included in our study had not received any physiotherapy intervention during the previous year. One might argue that the sample was well functioning and therefore representative for a specific group of people with PD. However, in reality, a patient with PD does not always receive treatment when it is required. As was reported in a study by Keus et al. In their paper, 41%of the patients from 95 patients (of a total of 235 patients) who were identified to have serious problems within at least one of the four core areas of physiotherapy practice in PD (posture, balance, gait, transfers) and were therefore regarded as requiring referral to physiotherapy, did not receive physiotherapy (Keus et al., 2004). We are rather convinced that accessibility to physiotherapy services in Estonia is worse than in the Netherlands where the before mentioned study was conducted.

The present study approves that different evidence-based physiotherapy recommendations can be incorporated into conventional physiotherapy programme in a manner easily applicable in clinical settings, having beneficial outcomes to the patients with PD. Patient-centred care has been increasingly recognized as an essential component of quality care that has a positive effect on patients’ performance and rehabilitation (Yun & Choi, 2019). The present is a valuable contribution to increase patient-centred management care. The study convincingly showed that the participants who received a guideline-based, structured conventional physiotherapy programme perceived a positive impact on self-perceived difficulties of basic ADL. The authors propose that future research should explore the long term effect of such conventional, guideline-based and structured physiotherapy intervention and should optimize a cycle of intervention. Also, recent research reports support intermittent, short term intensive interventions (Welsby et al., 2019). Patient’s perception is necessary to consider in research and clinical practice with individuals with PD, so important issues would not be missed.

5Conclusions

The outcomes of this study revealed that 2-months of physiotherapy intervention in a group environment that was focused on all the core areas recommended in physiotherapy guideline reduced patient-perceived difficulties in basic ADL in PD patients.